HPLC-Chip/MS for Biopharma Characterization

Get the accurate results you need from a single LC/MS solution.

The Agilent HPLC-Chip/MS solution enables highly accurate and sensitive characterization of biopharmaceuticals that makes it possible to routinely use highly sensitive nano-LC/MS analysis in development, where reliability, ease of use, and accuracy are absolutely critical.

Fill out the form to access HPLC-Chip/MS biopharmaceutical application notes or to have an Agilent Representative contact you to discuss the HPLC-Chip/MS Solution.

Available application notes include:

mAb Glycan Analysis - The mAb-Glyco Chip integrates the whole N-glycan workflow into a single chip, using an integrated PNGase enzyme reactor and nanocolumns for analysis in minutes rather than hours or days

Intact Biologic and Impurity Analysis - Separation of mAb heterogeneity, confirmation of mAb deglycosylation, and accurate identification of Fab and Fc fragments

Oxidation Analysis - Analysis of intact proteins and protein digests to determine the amount of oxidation and sites of oxidation

Peptide Mapping - Sequence coverage of the light and heavy chains of a monoclonal antibody is possible in less than 40 minutes