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New Brunswick Scientific has introduced a new benchtop cell culture bioreactor that combines single-use technology with the trusted performance and true scalability of a stirred-tank design.

CelliGen BLU has been engineered for high-density animal cell culture in research or production, using interchangeable, single-use, stirred-tank vessels in 5.0 and 14.0 L total volume capacities. A compact controller enables advanced process management for research or cGMP manufacturing.

Key Benefits

• The single-use vessel eliminates autoclaving and cleaning, provides rapid turn-around between runs, reduces risk of contamination, reduces validation requirements and minimizes initial startup costs
• The integrated control station enables advanced gas management and process control
• Stirred-tank design provides proven performance and scalability
• Unique pH and DO technology makes probe insertion totally noninvasive and autoclaving unnecessary

Single-Use Vessel, Stirred-Tank Design

Interchangeable, rigid-wall, 5 and 14 liter stirred-tank vessels come pre-sterilized and ready for use — no cleaning, autoclaving, or assembly needed. All vessel components in product contact are made of USP Class VI materials and have been tested for leachables and extractables, making them appropriate for GMP environments.

Vessels Include:

• Bi-directional, pitched-blade impeller
• Microsparger
• pH sensor
• Tubing (silicone and C-Flex®, for use with tube welders)
• 0.2 μm Filters
• Sealed magnetic drive

Ports and Penetrations:

• RTD/temperature
• Noninvasive optical pH
• Noninvasive polargraphic DO
• Additions (3)
• Harvest
• Overlay
• Sparge
• Sampling
• Exhaust line with heater

Compact Control Station

New Brunswick's powerful RPC (Reactor Process Control) firmware provides integrated control of up to 32 process parameters, and includes time-saving recipe features, built-in security and ability to simultaneously monitor up to eight parameters on user-customized trend graphs.

Sophisticated Control Station includes:

• Industrial touchscreen interface with adjustable position, 15" (38 cm) color display
• 3 integrated pumps (with option to add more)
• Magnetic-drive motor
• Control of temperature, pH, DO and 3- or 4-gas mixing
• 7 analog inputs and 7 analog outputs for addition of ancillary devices
• Media bag hanger

Gas Flow Control Options

• 1, 3 or 4 Thermal Mass Flow Controllers (TMFC) or a Rotameter for sparge gas
• Rotameter or TMFC for optional gas overlay

Additional Options

• Scale for measuring additions and harvest
• Validation packages
• Gas regulators
• Media/supplement addition kits
• BioCommand® SCADA software