The MultiMode PicoForce scanning probe microscope system brings unprecedented accuracy and flexibility to molecular biology and nanoscale materials research. With its innovative force-measurement features, proven SPM technology, and high-speed fifth-generation NanoScope V controller, the MultiMode PicoForce is ideally suited for a broad variety of studies, from protein unfolding and antigen-antibody binding to membrane elasticity. The system's handheld PicoAngler tool allows users to manually explore tip-sample interactions with incredible ease. This innovative tool is particularly useful for single-molecule force spectroscopy, providing highly sensitive approach and retraction of the cantilever tip.