Active Pharmaceutical Ingredient Fermentation

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• Getting the Most from Coriolis Flowmeters in Pharmaceutical Processes
  performance and repeatability. Formulation There are also some opportunities for flow measurement devices during pharmaceutical formulation, which is characterized by smaller-scale handling of the Active Pharmaceutical Ingredient (API) and/or other ingredients. Handling of the Pure API Once...
• The Greening of a Roche API Process: Pollution Prevention Pays
  process development specialists combined two processes into a single, more environmentally friendly process, which is now used to manufacture a key active pharmaceutical ingredient (API) at its Clarecastle facility. Among other things, the redesigned process increased yield. It also reduced solvent...
• Weighing and Dispensing: Do it Right
  include: active pharmaceutical ingredients (API), solid dose forms (SDF), liquids, ointments and creams (LOC), sterile injectables (SI), and biopharmaceuticals (cell culture and fermentation). Raw Material StagingRaw material and work-in-process staging should be directly adjacent to the weighroom, thus...
• Green Processing
  , from fermentation sources instead of petroleum feedstock. This idea is anything but pie-in-the-sky. Microbia (Cambridge, Mass.), a discovery and development pharmaceutical company with two drugs in early-stage clinical testing, uses molecular biology and genetics to optimize production...
• From the Editor: Operator Error: Does the Industry Have ADD?
  medication that contained up to three times the active ingredient required. Fewer than 500 bottles from this lot are in circulation, but one can only hope that this medicine doesn t reach any children. The fact that errors like this can occur in an industry as heavily regulated as pharmaceuticals...
• Beware Thermal Cycling in BioProcessing Part One
  from the organs and tissues of animals, which are much more fragile and more difficult to grow. A complete system for manufacturing an active ingredient for a biopharmaceutical product is made up of tanks and vessels, pumps, centrifuges, and other rotating equipment, as well as various kinds...
• Weighing and Dispensing: Do it Right
  depends on the type of processing that will take place in the process area. Manufacturing operations can include: active pharmaceutical ingredients (API), solid dose forms (SDF), liquids, ointments and creams (LOC), sterile injectables (SI), and biopharmaceuticals (cell culture and fermentation). Raw...
• PAT Provides New Insights Into Drying
  (Application Prototyping System) NIR spectrometer--as small as a matchbook--bravely goes where no full-sized instrument has gone before: into the working environment of an active pharmaceutical ingredient (API) process dryer.In one early installation, Axsun designed a special gas cell...
• Going Small, Thinking Big
  1 | 2 | 3 Next >> View on one page By Paul Thomas, Managing Editor Plenty of drug makers today are thinking small. Real small. In the neverending pursuit of a better route to certain intermediates and active pharmaceutical ingredients (APIs) and more streamlined operations, drug companies...
• Tech Transfer: Don't Fumble the Hand Off
  to 20,000 L, we begin to see solubility and stability problems that may result in unacceptable levels of impurities and byproducts.” Neutralizing an acid form of an active pharmaceutical ingredient (API) with sodium hydroxide works, but this strong base can react with the drug when it is added too rapidly...

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