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  • Tangential Flow Filtration Explores New Niches
    is not wholesale, however, notes Kent Iverson, an independent biologics CMC consultant. Take clarification of cell culture broth. TFF is actually being replaced by centrifugation in many plants, and by direct flow "dead-end " filters in others --they 're often simpler and cheaper,
  • Downstream Bioprocessing: More is More
    steps are added as needed to reduce virus levels to FDA/EMEA standards. Most dedicated viral clearance methods involve tradeoffs. For example dead-end filtration often results in unacceptable protein losses. Filters clog, involve long processing times, and sometimes break through, notes Maik Jornitz
  • Treating wastewater from CMP using ultrafiltration
    that some form of cross-flow filtration should be used for their removal, as opposed to dead-end or once-through cartridge filtration, which would be quite expensive in terms of consumables. There are also several reasons why ultrafiltration (UF) technology should be chosen over microfiltration. As seen

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