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  • Tangential Flow Filtration Explores New Niches
    is not wholesale, however, notes Kent Iverson, an independent biologics CMC consultant. Take clarification of cell culture broth. TFF is actually being replaced by centrifugation in many plants, and by direct flow "dead-end " filters in others --they 're often simpler and cheaper,
  • Downstream Bioprocessing: More is More
    steps are added as needed to reduce virus levels to FDA/EMEA standards. Most dedicated viral clearance methods involve tradeoffs. For example dead-end filtration often results in unacceptable protein losses. Filters clog, involve long processing times, and sometimes break through, notes Maik Jornitz
  • Medical Device Link .
    . Dead-end filtration is easy to assemble, but the likelihood of clogging is high. This method reduces the risk of cross-flow filtration where the filter membrane is mounted horizontally to the flow direction, but efficiency is also reduced. So-called H-filters (channels structured like an H shape
  • Medical Device Link .
    methods of removal together with their respective advantages and disadvantages are described below. n Dead-end filtration is easy to assemble, but the likelihood of clogging is high. This method reduces the risk of cross-flow filtration where the filter membrane is mounted horizontally to the flow
  • Medical Device Link .
    High-flow pinch valves are suitable for applications requiring high purity, zero dead volume, or particulate handling. The S-line of valves includes two-way normally closed, two-way normally open, and three-way universal constructions and can handle tubing sizes ranging from 1/16 to 3/8 in.in
  • Medical Device Link .
    liquid from openings within sliding port plates. While sliding, the ceramic port plates form a hermetic seal that does not allow for fluid leakage. These port plates offer a recessed area that matches the tip of the piston, forming a tight seal without dead volume. Because there is no clearance between
  • Treating wastewater from CMP using ultrafiltration
    that some form of cross-flow filtration should be used for their removal, as opposed to dead-end or once-through cartridge filtration, which would be quite expensive in terms of consumables. There are also several reasons why ultrafiltration (UF) technology should be chosen over microfiltration. As seen
  • Medical Device Link .
    of chemicals and reagents can be used in kidney dialysis, chromatography, and syringe-filling applications. The pump, also available in a diposable model, features pulseless continuous flow, 100% volumetric efficiency, zero leakage, and near zero dead volume. It offers digital control and continuous

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