Drug Milling

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• Milling Equipment FAQs
  ) mill will grind pharmaceutical powders fine enough to pass through a hypodermic needle. An increase in potency can be achieved with an increase in surface area so a lower dosage of the drug is required to do the same job. Fillers and extenders such as clay and silica products are precisely milled...
• Free Webinar: Media Milling Techniques for Submicron Size Reduction
  . Topics. Aseptic Processing. Automation & Control. cGMPs Compliance. Contract Manufacturing. Drug Delivery. Facilities & Support. Facility of the Future. Fill Finish. Focus on Pharma Podcast. Funny Pharm. Green Library. Industry Developments. Operational Excellence & Lean Six Sigma. Packaging. Process...
• Pharmaceutical / Nutraceutical Processing Applications: Milling and Micronization of Pharmaceutical Powders
  the hazards of the drug and protection of the dry compound from the hazards of the surrounding environment. In designing such milling systems, it is imperative that the feeding device used be completely accessible and dismantled through the use of gloves in glove ports. Integration of the K-Tron Pharma...
• Controlling Crystallization through Modeling
  in drug manufacturing. CSD control is critical to successful crystallizer operation and to product quality and purity, as CSD often impacts downstream processing such as filtration, centrifugation and milling. Size distribution also affects the rate at which a powdered material dissolves in the body...
• Quality by Design in the Design Space
  Process Analytical Technology (PAT) facilitates the implementation of Quality by Design (QbD). It is a system approach that defines the desired product performance. According to Ms. Chi-wan Chen, Director of the Office of New Drug Quality Assessment, CDER/FDA, QbD is an opportunity to identify...
• Particle Analysis for the QbD Era
  The current climate of risk management and Quality by Design has pharmaceutical R&D and manufacturing professionals searching for fast, automated analysis of microparticles for raw materials, drug powders, or parenterals. ASPEX Corp. (Delmont, Penn.), in conjunction with a major pharma company, has...
• Achieving Operational Excellence in Pharmaceutical Manufacturing (.pdf)
  for the multi-billion dollar Western global. milling, compacting, coating and even some packaging is still. drug corporations. manual in nature. It still requires a human to weigh out a given. amount of Active Pharmaceutical Ingredient (API); people still. Initiatives such as Process Analytical...
• Controlling Crystallization through Modeling
  size distribution (CSD) is one of the key challenges in drug manufacturing. CSD control is critical to successful crystallizer operation and to product quality and purity, as CSD often impacts downstream processing such as filtration, centrifugation and milling. Size distribution also affects...
• Containment Technologies Group
  box would accommodate the operations of weighing active drug, granulating, milling, blending, and tabletting. An initial cleaning of residual powder would be performed inside the glove box and then the equipment would be removed for final cleaning and breakdown during which lab personnel would...
• Building a Business Case for PAT
  . Determination of Physical Properties (Moisture Content, Particle Size)II. Manufacturing A. Drying & Milling B. Granulation & BlendingIII. QC A. Content Uniformity of Drug Product B. Statistical Analysis of NIR Images of Drug ProductWe want to determine the Value Added Indicators...

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