Effusivity Measurement

Conduct Research

• Explorations in Effusivity
  were able to establish blend endpoints based upon effusivity readings (rather than based upon time), then take samples to the lab for chromatography analysis. The two measurements correlated down to 0.5% with active ingredients, Closs noted.Patheon is also studying effusivity's role in measurement...
• PAT: An Excipient Supplier's Perspective Thermal effusivity -- Inter-lot variability for commonly used pharmaceutical excipients
  indistinguishable. This creates an opportunity for effusivity to be used in identifying incoming raw materials. Also, by monitoring the variability in effusivity measurements on several lots of AvicelA(R), it is possible to determine its consistency compared to other excipients or other sources of microcrystalline...
• PAT Provides New Insights Into Drying
  , effusivity requires that materials be diverted from a fluid bed dryer. Its speed (one measurement per minute) and resolution (about 0.25%) permits moisture determinations in near-real time. The goal is process understanding Increasingly, says Mathis, manufacturers interpret the PAT guidance as covering...
• Application of IR - NDT to Different Aeronautical Plastic Materials (.pdf)
  of aeronautical plastic material defects. The response of the surface temperature to heating has been used to detect subsurface features of defects by means of the plastic sample cooling sequence. Low thermal diffusivity and effusivity of plastics shows a slow process of heat conduction in samples...
• PAT Takes Manhattan -- and San Juan
  applications got the PAT label. But what truly qualifies as PAT? That was a question being raised in the sparsely attended sessions and workshops away from the show floor. Nancy Mathis, president of thermal effusivity sensor maker Mathis Instruments, led off one workshop by discussing email correspondence she...
• USP's Gary Ritchie with an Update on PAT Standards Development
  came on board with 1119, for NIR spectroscopy. Then there were the chapters that I did bring in for Raman spectroscopy, acoustic emission and effusivity. And now, we are looking at revising some of the waters chapters. 643 and 645 were originally devised as lab off-line tests, but were revised...
• PAT in Perspective: Drugs Are Not Potato Chips
  By Emil W. Ciurczak, Cadrai Technology Group Chemometric analysis of monitoring instruments provides this control. Methods such as NIR, FT-IR, thermal effusivity, acoustics, Raman, rapid LC, pH, temperature, flow rates, etc. give a signal used in following the process. Based on previous lots...
• PAT Provides New Insights Into Drying
  . Vendors, manufacturers team up to roll out the latest in mass and NIR spectrometers, effusivity sensors and other PAT-worthy technologies. To cast your vote, log in or become a member. This quick, one-time registration gives you access to members-only site benefits. 1 vote. Share. Print. Related. RSS...
• New Methods for the PAT Toolbox
  of heat to objects with which they come in contact, and instantly measure how much heat reflects back to them. Like fingertips, effusivity sensors are interfacial, supplying both the heat and measurement. Since they measure an intensive property rather than an extensive property (e.g. total heat) samples...
• PAT: Gateway to Advanced Control for Operational Excellence
  clean in place (CIP) and checkweighing. Thermal effusivity sensing is another advanced analytical technique that is now migrating into pharmaceutical applications. One new sensor from Mathis Instruments, for example, precisely measures the moisture endpoint in a fluidized bed dryer while minimizing...

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