High Capacity Fermentation

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• Cocoa Fermentation Using Wireless Monitoring
  was extremely painstaking, but without closely-monitored fermentation, the cocoa beans would. not result in high-quality chocolate. Therefore the manufacturer required a wireless monitoring solution. which could communicate with office computers to ensure that the temperature and humidity inside. the sweatboxes...
• Fermentation and Cell Culture: Get it Right
  with regard to facility construction." Small is big Large-scale cell culture came of age with the success of high-dose, chronically administered monoclonal antibodies (MAbs). While the number of cell culture processes with 10,000L, 20,000L, and higher capacities is growing, most cell cultures...
• Fermentation and Cell Culture: Get it Right
  specify a high level of in-process monitoring. After acquiring Braun in May 2004, Sartorius consolidated operations from four smaller buildings into a new, 85,000-square-foot manufacturing site. The company has also expanded its product line to include more media preparation and filtration...
• What Capacity Crunch?
  small, in the view of Finnegan and others, to absorb modest increases in demand. Uncertainties related to product approval and high capital investments still operate, however, especially for firms that lack captive capacity. "You don't really know if you will need large-scale manufacturing until fairly...
• Dissolved Oxygen Measurment in Brewing Process (.pdf)
  oxidation can occur. At the end of fermentation. rapid fermentations (resulting in excessive yeast growth and. the green beer is totally anaerobic and free from oxygen. beer losses), and high ester production, resulting in a fruity-. The yeast is then skimmed off or allowed to settle, and the. tasting...
• Cost-Driven Chromatography
  utilization (including reuse) and higher product recovery; alternative downstream strategies that employ membrane adsorbers, liquid-liquid separations, and of course, disposables. High process volumes and protein titers stress the capabilities of downstream operations in general, and chromatography...
• Improved Wastewater Treatment at Hess Collection Winery
  - such as cleaning of the crusher, pomace conveyors, presses, and fermentation tanks - can also generate high strength wastewaters. Other process wastewater includes washing of storage tanks, bottling and other equipment, and wine racking. Total Hess Collection Winery wastewater includes the process wastewater...
• When Less is Much, Much More
  microreactors for R&D. Compared to traditional batch reactors, the smaller devices can tolerate extremely high temperatures and pressures, above 650oC and 25 bars. Microreactors can also use reagents that are between five and 100 times more concentrated ? 5 M is common ? than the solutions used for solution...
• Vaccine Manufacturing Reborn
  vaccines simply do not work without an adjuvant.Dowpharma has seen its adjuvants business triple since 2005, due in large part to the success of its Pfénex (pronounced “phoenix”) platform protein expression technology. The company expects high growth to continue based on existing projects.Because it uses...
• Think Small
  accommodations need to be considered for these projects outside of the chemical process industries. The high margins that many pharmaceutical products can command and the tight federal regulatory environment under which these companies must function mean plants must take measures to ensure...

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