High Throughput Fermentation

Conduct Research

• Fermentation and Cell Culture: Get it Right
  for working on media, developing custom nutrient blends takes months and is not easily defended during hectic product launches. Reproducible high-throughput methods have been elusive due to issues with evaporation, mixing and maintaining homogeneity in ultra-scaled-down systems. Plus, each experiment...
• Cost-Driven Chromatography
  .), Pall now offers high-throughput chromatography screening services for rapid process-scale chromatography methods development. Based on SELDI mass spectrometry, the service rapidly screens binding and elution conditions on the Ciphergen ProteinChip array coated with various adsorptive...
• Robust Vacuum Solutions in Biomass Processing (.pdf)
  . equipment suppliers cannot only refer to existing similar. plant requiring vacuum equipment are given later but. applications to determine the right pressure level, but. whether it is low or high pressure generation, both are. also the correct technology to use on related biomass. created using compressors...
• When Less is Much, Much More
  microreactors for R&D. Compared to traditional batch reactors, the smaller devices can tolerate extremely high temperatures and pressures, above 650oC and 25 bars. Microreactors can also use reagents that are between five and 100 times more concentrated ? 5 M is common ? than the solutions used for solution...
• Seagram's
  as not to disturb. Magnetostrictive sensors offer an inherently high degree of. distillation processing. Most tanks had existing holes at. accuracy (non-linearity 1/32" or 0.794 mm) and repeatability. the top of each tank. Because MTS gauges calculate tem-. (0.01% full scale) without drift. The sensors operate...
• Question of the Month: Is Biopharma Ahead of the PAT Curve?
  to allow the subtleties of the problem space to be explored. Therefore, process performance is dictated (in general) by empirically derived operating parameters that may be sufficient to ensure production, but are insufficient to ensure consistency and high yield. Many factors may change the operating...
• Environmentally-Friendly Machining Systems (.pdf)
  www.datrondynamics.com. t h e s c i e n c e b e h i n d t h e s o l u t i o n © 2003. All rights reserved. fermentation process. It is ideal for high-speed, micro-tooling of non-ferrous metals and some. plastics due to a thinner-than-water viscosity that allows the ethanol to quickly cover and cool...
• In Search of Consistency
  an existing process," notes Tim Gregory, senior director of process sciences at Genentech (South San Francisco, Caif.). But new separation technologies that interest Gregory are tangential flow filtration (TFF) and a new wrinkle: high-performance tangential flow filtration (HPTFF), which reduces...
• Going Small, Thinking Big
  at the production level. Consider projects that, when successful at the laboratory bench-scale, easily translate to the process scale. Take the limitations of microreactors at the process scale (throughput, pressure drop, etc) into consideration before choosing the R&D application. Remember that high...
• Going Small, Thinking Big
  , high-quality, continuous flow drug manufacturing. Specific ApplicationsMicroreactors and microchannel devices are showing their worth in a variety of ways, though without much coordination or standardization as of yet.Dr. Xini Zhang and researchers from Johnson & Johnson Pharmaceutical Research...

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