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  • Cleaning Validation Re-Imagined
    , they are. absolutely unwilling to increase product contamination. Cleaning (including labs) - 61%. risk and, therefore, have typically over-engineered. cleaning processes at the cost of efficiency. For the past ten years, we have been working with. hundreds of customers globally to develop analytical
  • Game Changers in Cleaning Validation and Verification
    not document on EURs?. Critical Steps Contributing. Without Game Changers. With Game Changers. to Cleaning Costs. Cleaning Process. No Change. No Change. Lab/validation teams created longer. Streamlined with manufacturing team. Sampling (Swab and Rinse). sampling times due to unfamiliarity
  • Checking Cleaning Efficiency of Metal Parts
    cleaning. The metal part was soaked in a known volume of Freon, then the solvent was tested for its hydrocarbon content. Since Freon is an infrared transparent solvent and does not contain hydrocarbons, it can be placed directly into a 10mm quartz cuvette cell and inserted into an InfraCal Cuvette Holder
  • Aqueous Ultrasonic Cleaning: Technology Improved by Use of Optimized Wire Cloth Baskets
    Part of the Weiss-Aug commitment to total quality is an attitude of environmental responsibility. As soon as the issue of removing harmful CFCs (chlorofluorocarbons) from ultrasonic cleaning solutions was raised, the company determined to convert its ultrasonic cleaning procedures from
  • Testing the Effectiveness of Baking Soda Media Blasting for Cleaning fungal contamination in Buildings
    While we have performed the baking soda media blasting technique many times to clean irregular building surfaces, here we report on a specific test case for which we collected a variety of samples selected to test the effectiveness of the cleaning process at several points. Remediation of large
  • The Advantages of TOC Analysis Over Traditional Product Specific Analytical Methods for Cleaning Validation
    in the lab can impact the production. is that the products, excipients, API’s, gels, oils, lotions,. schedule and equipment utilization, require significant. or proteins are usually degraded by a cleaning process. lab resources, and prolong product change-overs for. that involves, hot, aqueous, alkaline
  • Ion Spectrometry to Cut Cleaning Validation Time
    Cleaning validation is a critical part of current Good Manufacturing Practice (cGMP), requiring manufacturers to spell out, and then verify, the procedures that they use to clean their equipment. After cleaning, operators typically use high pressure liquid chromatography (HPLC) to sample reference
  • Control of Xylene Vapors in a Lab Setting: O-Xylene Vapors (.pdf)
    used often as a chemical intermediate. Xylene is also used in the semiconductor industry because it is a good cleaning agent. for silicon wafers. It is also used as a sterilizer. However, xylene vapors are toxic and. extended exposure can lead to problems in the respiratory tract. Consequently