Powder Friability

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• Improving Control of the Extrusion Spheronization Process
  , by reducing variations in gastric emptying rates and overall transit times. Pharmaceutical pellets are typically manufactured via extrusion spheronization, a three-step process introduced in the late 1960s, that results in spherical granulates roughly 1 mm in diameter. In this process, the powder is formed...
• Improving Control of the Extrusion Spheronization Process
  , that results in spherical granulates roughly 1 mm in diameter. In this process, the powder is formed into a wet mass, which is forced through a restricted area (extrusion) to form strands of extrudate that are broken into short lengths and rounded by placement on a rotating plate within a cylinder.The...
• Particle Size Analysis of Cocoa Powders (.pdf)
  beans to obtain a paste called cocoa. liquor. Adding preground sugar, flavourings or additives. Crystal Sugar. will result in pure cocoa powder or a dry mixture. Grinding controlled. Finally, a granulation phase obtains a mixture. « DRY MIXTURE». used for the production of powdered drinks. Control...
• Improving Control of the Extrusion Spheronization Process
  . Gazzaniga et al.13 found differences in the friability and particle size of pellets when the powder mass was wetted with different quantities of water.Starting MaterialThe physical nature of the starting material influences the particle size, hardness and sphericity, as well as the release rate...
• Compressing Force: Myth vs Reality
  for compressing force will display a constantly changing number, however slight, with slight changes of powder mix or uniformity of the mix density. Therefore, the numbers reported in the tables and reports that one reads in scientific literature are actually approximate descriptions of what was going...
• Containment Technologies Group
  solid powder residue that can become airborne. The filling process can aerosolize liquids where micro aerosols are generated from the filling heads of the line. Semi-solids: Semi-solids present little potential for aerosolization and are primarily a skin contact hazard in packaging if volatile...

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