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• Pilot Plant Partnerships
  for a 33-step synthesis that includes several esoteric reagents or proprietary catalysts. "Even then," comments Vijay Samant, CEO of San Diego-based Vical, Inc., "when they outsource it's usually to make room for pipeline products." Outsourcing needs change during any product development cycle. Early...
• Leaning on NIR in Pisa
  By Nicola Cecconi, Abiogen Pharma S.p.A. and Emiliano Genorini, Thermo Fisher Scientific Neither is there a need for sampling if the analysis is done in the dispensing area. In addition, there are cost savings on reagents and other chemicals. However, analysis must be carried out by non-specialized...
• Leaning on NIR in Pisa
  . Different methods were specified for each raw material to be identified — a time-consuming process. It also was costly, not only the outlay for different instruments, reagents and other chemicals, but also the decreased productivity of laboratory instruments and personnel.Traditionally, raw material...
• Green Processing
  renewable feedstocks Employ catalysts instead of stoichiometric reagents Avoid chemical derivatives Reduce solvent use or use safer solvents and reaction conditions Improve energy efficiency Design in biodegradability Analyze in real time to prevent pollution Minimize accidents Recover all elements...
• Throwing it All Away
  fermentations will probably not benefit any time soon since process bags are limited to about 2,000-liter volumes. Similarly, already-approved processes are unlikely to switch over. Non-biotech drugmakers, whose processes often employ organic solvents, high heat and caustic reagents, will probably...
• The role of sodium silicate
  by the recycling plant, although slightly different amounts of chemical reagents are used. These methods are detailed below. The experiments in each series were repeated at least five times in order to obtain statistically significant results. 2.2 Laboratory pulping method Based on the work...

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