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The image quality of a two-photon microscope is often degraded by wavefront aberrations induced by the specimen. We demonstrate here that resolution and signal size in two-photon microcopy can be substantially improved, even in living biological specimens, by adaptive wavefront correction based...

Mice are an excellent model for studying mammalian hearing. and transgenic mouse models of human hearing, loss are commonly. available. However, the mouse cochlea is substantially smaller. than other animal models routinely used to study cochlear physiology. This makes study of their hair cells...

Several laser-scanning microscopy techniques have been developed in the last twenty years based on non-linear optical phenomena.1 This has led to a variety of powerful imaging tools, such as two-photon excited fluorescence microscopy (TPM),2 second harmonic generation (SHG) microscopy...

We propose two-photon excited fluorescence (TPEF) microscopy employing a novel phase modulation technique of ultra-broadband laser pulses, which allows the relative excitation of an individual fluorophore with respect to other fluorophores. This technique is based on the generation...

...provide optical sectioning required for 3-D resolution. On the other hand, techniques that do provide 3-D resolution, such as confocal or two-photon microscopy, typically offer only limited fields of view and penetration depths.1 Macroscopic imaging with such techniques is quite laborious...

An opening in the mouse skull, or cranial window, enables imaging the neurons in the living brain using two-photon microscopy. But using this approach, one can generally only image the most superficial layers of the cortex. To overcome this, Andermann et al. use microprisms. They inserted 1-mm...

...high-resolution three-dimensional assays based on two-photon microscopy can be performed only in these regions of interest. We further show that three-dimensional morphology extraction algorithms can be used to analyse the resultant high-resolution two-photon image stacks providing information...

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