Reminiscent of the 1966 movie Fantastic Voyage, the medical mini-submarine developed by Tel Aviv University, Israel researchers signals progress in merging a drug candidate with a therapeutic delivery system. Used like a nano GPS system, it navigates the body. The biological nano-sized carrier will deliver RNA interference drugs to target cells, eliminating faulty proteins, restoring diseased cells, or killing cancerous ones. The diminutive dreadnought has homed in on leukocytes in lab mice with ulcerative colitis. Potential for the nano-submarine to address brain, breast, pancreatic, and other pathologies will be tested in near-term clinical trials.

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A team of Canadian scientists has imparted intelligence to metals used in medical implants. Chemical modification with specific etching mixtures yields nanoporous surfaces that stimulate bone building or retard unwanted cell growth. It is a clever way to improve healing and the success of metal implants and prosthetics.

A Medical Product Manufacturing News article confirms the product engineering benefits of advance collaboration. Consulting with an injection molding specialist fine-tuned designs for a disposable breast coil system and biopsy device. Collaboration led to alternative material selection, better structural integrity, lower cost, and faster market introduction.

The motor that moves a sensor-equipped miniature robot through human blood vessels is just 0.25 mm wide. This video shows how the scaled-down piezoelectric design effects in vivo microbot propulsion with output power of 4.25 μW. Remote-controlled mini-devices will aid minimally invasive surgery by increasing a surgeon's view and dexterity.

If you found this subject interesting, subscribe to GlobalSpec's e-Newsletter DirectU2 The world of Motors.

Research expands on a non-coplanar mesh design that embeds electronics into flexible materials. The material retains electrical properties while bending up to 140% and corkscrew twisting up to 90 degrees. Flexibility comes from the silicon islands on which circuits are fabricated. It may stretch the boundaries of implantable design.

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Capturing the amorphous geometry of human hands to design custom prostheses for partial finger amputees was enabled with a laser scanning system. Scanned hand casts cut the time needed to create 3D digital CAD models by 60%. Medical Design Technology cites accuracy to within 0.05 mm of the actual cast.

Data collected by Europe's Osteoporotic Virtual Physiological Human Project helps product development software model structural and fluid flow dynamics. Patient-specific simulations based on conventional diagnostic imaging aid fracture risk and location assessment. Merging simulation technology with diagnostic imaging should improve osteoporosis onset projection accuracy.

Improved patient compliance and safety are the goals of merging next-gen electronic dry powder inhalers and remote patient compliance monitoring. Drug use data is wirelessly communicated via on-board chips to patients and doctors. User alerts remind patients to follow drug regimens, while real-time tracking aids clinical trial data management.

Partnering helped take the sting out of needle-free insulin injector redesign. Use of injection molded silicon rubber provided design freedom that shaved product size, weight, and part count and corrected lubrication problems. Design News documents simplified operation for the user and a streamlined supply chain for the maker.

Power Solutions Inc. is now offering its new INDUSTRIMOD™ family. This product family includes the EASYMOD®, MINIMOD™ 20 to 350 W universal AC input, and DCMOD™ 24 or 48 VDC input switching power supplies. Available in industrial grade temperature range of -40° C to +85° C; all units are 1U high maximum.

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