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Anion Analysis of Ophthalmic Irrigation Solutions with the Shimadzu Prominence IC System

From Shimadzu Scientific Instruments, Inc.
 

 

Ophthalmic solutions suitable for eye irrigation, eye strain relief, contact lens storage and tear replacement abound in the marketplace. While some of these serve as convenient agents for administering medicines in minute quantity, many are formulated to act as cleaning agents and may contain only dissociated ions like chloride or sulfate and organic preservatives such as benzalkonium chloride. The physiologic pH of blood and tears is approximately 7.4, but a pH range of 6.5 to 8.5 will prevent damage to the cornea. This is accomplished using buffers. To prevent eye tissue damage and maximize comfort, solutions are made to be iso-osmotic (equal osmotic pressure) with tears. The common term for this is isotonic. A 0.9% NaCl solution in pure water is said to be isotonic with tears. In this application note we will aid in the quality control of such ophthalmic solutions for their content of common anions.

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