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Selecting Modulating Valves and Clean Steam Traps for Sterilization in Place (SIP) Systems

From Jordan Valve Group
 

 
In today's pharmaceutical systems, SIP processes are becoming more and more critical. The nature of batch processing and the relationship between time and temperature for sterilization demand highly efficient SIP processes. The associated valves and steam traps must perform with high efficiency while meeting the stringent cleanliness requirements of the pharmaceutical and biotech industries. This article will discuss key elements of control valve, pressure regulator and steam trap design for use in clean steam systems. Design considerations, selection criteria and performance expectations will be reviewed to further assist engineers and users during the specification process Pharmaceutical Sterilization-in-Place (SIP) systems are designed to sterilize a collection of process equipment after a batch of product is completed. Equipment such as bioreactors, fermentors and the accompanying tubing must be cleaned and/or sterilized before a new production cycle can ensue. These systems are constructed from high grade stainless steel materials as well as from FDA or USP approved flexible materials (i.e. Teflon® - lined piping).
Products & Services
Tempering valves and thermally actuated valves contain a thermal sensing component that opens or closes in response to temperature changes. Search by Specification | Learn more about Tempering Valves and Thermally Actuated Valves
Plastic valves are made from plastic materials and are used in applications that require corrosion resistance and/or chemical handling. Search by Specification | Learn more about Plastic Valves
Pressure relief valves are self-actuated safety valves designed to relieve excess pressure upstream from the line. Search by Specification | Learn more about Pressure Relief Valves
Control valves or proportional valves are power-operated devices used to modify fluid flow or pressure rate in a process system. Search by Specification | Learn more about Control Valves
Gate valves and knife valves are linear motion valves in which a flat closure element slides into the media stream to shut off flow. Search by Specification | Learn more about Gate Valves
Product Announcements
New Brunswick Scientific - Production Fermentors & Bioreactors: BioFlo Pro
New Brunswick Scientific line of large-scale fermentors (75 to 3,000L) and bioreactors (75 to 650L) are modular in design, to allow ready customization, quick delivery, and the ability to expand... (read more)
New Brunswick Scientific - Pilot to Production Fermentors & Bioreactors
New Brunswick Scientific's new BioFlo 510® Sterilizable-in-Place (SIP) Benchtop Fermentors and CelliGen 510 Bioreactors, in 19.5 & 40 Liters, provide the ultimate in convenience, system... (read more)
Colonial Seal Co. - Sealing Materials for Medical Devices
Colonial Seal supplies specialty seals to OEM's in Medical Equipment, Pharmaceutical Processing and Food & Beverage Equipment manufacturing. We supply various grades of PTFE and filled PTFE, FDA... (read more)
ALMATEC Maschinenbau GmbH - BIOCOR Aseptic Pumps
The ALMATEC pump series BIOCOR is especially designed for sterile applications within the pharmaceutical, biotechnical and food industry. The air-operated diaphragm pumps are EHEDG certificated and... (read more)
ALMATEC Maschinenbau GmbH - Pump Solutions for Sanitary Applications
The ALMATEC pump series BIOCOR is especially designed for sterile applications within the pharmaceutical, biotechnical and food industry. The air-operated diaphragm pumps are EHEDG certificated and... (read more)
Jaygo, Inc. - Mixing & Homogenizing Systems
Designed for production of high quality pharmaceutical and cosmetic emulsions, creams, gels and lotions. Produces astonishingly fast batches while maintaining the highest product quality possible... (read more)
Topics of Interest
To respond to legislative and customer requirements, the pharmaceutical industry is having to demand ever increasing standards of hygienic construction in process equipment. This is applicable to all... (Read More)
Pumping fluids containing microorganisms - especially in the areas of pharmaceuticals, foods and beverages, and waste water purification - has always been a problem in the chemical process industries. (Read More)
Communications Communications for SIP are quite simple, unless capacity constraints force you to limit simultaneous steam draws by different systems. In the simplest of designs, the steam system... (Read More)
Path Confirmation To confirm that the flow path is properly set, there is typically a requirement for feedback on solenoid valves and any transfer panel positions. This is important to ensure... (Read More)
SIP Process Description and Challenges The Steam-In-Place (SIP) System is responsible for repeatedly steaming areas of product contact, including vessels, flow paths, and sample ports. This may be... (Read More)
See more product announcements for Tempering Valves and Thermally Actuated Valves
HAT/SP

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Therm-Omega-Tech, Inc.


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Therm-Omega-Tech, Inc.


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