By Angelo De Palma, Ph.D., Contributing Editor To keep up with new opportunities for chiral materials, BASF has doubled its chiral business development team. This group anticipates the markets needs for chiral synthons and intermediates by scouring public and private databases for chiral pipeline compounds. When something promising shows up, the team proposes possible chiral synthons and intermediates to serve the needs of development, scale-up, and manufacturing. We talk with chemists and in some cases provide very small quantities of new building blocks, says Stein. With its 2001 acquisition of U.K.-based Chirotech, Dowpharma (Midland, Mich.) has redoubled its efforts at providing a complete chiral tool kit to pharmaceutical customers. Chirality is very dear to our hearts, says Mark Cassidy, Ph.D., business director for small molecules. Theres not a single therapeutic class today that is not affected by it. Dowpharmas specialties are asymmetric hydrogenation, chiral hydroformylation and biocatalysis, for which the company utilizes both proprietary and commercially-available catalysts and enzymes. With the diversity of NCEs, drug sponsors can no longer rely on a single transformation or capability. Customers dont want that one-size-fits-all approach, says Cassidy. We operate in a custom market and the business models we practice also must be customized to meet to our customers needs. Dow supplies early-stage chiral synthons and registered starting materials through Asian manufacturing partners. More advanced, regulated chiral intermediates are manufactured in Europe or at Dowpharmas main facility in Midland. Proprietary chiral intermediates, catalysts and biotransformations may also be supplied or licensed to customers or their designated contractors. Chiral reagents and simple intermediates are increasingly sourced overseas. James Gao, Ph.D., sales manager at D-L Chiral Chemicals (Monmouth Junction, N.J.) represents custom- and bulk-synthesis companies in his native China. We learned very well from Wal-Mart, says Gao. We buy cheaply from Asia and sell here at a
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Biotechnology and Pharmaceutical Manufacturing Services
Biotechnology and pharmaceutical manufacturing services active pharmaceutical ingredients, sterilize biomedical components or materials, validate processes or packaging, and formulate drug or medicinal preparations on a contract basis.
Polarimeters determine the amount of polarization of light.
Specialty Polymers and Resins
Specialty polymers and resins are proprietary polymers, resins, monomers and intermediates. They include products that are based on proprietary curing technologies or chemistries, or that are designed for specialized applications.
Catalysts and Initiators
Catalysts and initiators start or promote chemical reactions used to produce organic chemicals, polymers and adhesives.
Topics of Interest
By Angelo De Palma, Ph.D., Contributing Editor For those who struggled through organic chemistry, the mere mention of stereochemistry terms, whether R and S, + and -, or levo and dextro, can bring on...
By Angelo De Palma, Ph.D., Contributing Editor If no difference is noted between racemate and pure isomer, fine. In cases where the single enantiomer is more toxic, sponsors must determine why and...
By Angelo De Palma, Ph.D., Contributing Editor Novozymes, part of the Novo Group (as in Novo Nordisk), is the worlds largest producer of industrial enzymes. Staff scientist Sevens Pearce, Ph.D.,...
By Angelo De Palma, Ph.D. Process optimization encompasses widely varying activities whose principal goal is to reduce costs by eliminating process steps, improving yields, shortening cycle times and...
By Agnes Shanley, Editor in Chief Advocates of increased funding for military research have always argued that spinoff technologies and applications more than justify the investment. They would seem...