Powder Blending From Art to Science

This quick, one-time registration gives you access to members-only site benefits. Spectral Dimensions has previously used the technique to analyze finished products in much the same way. NIR Chemical Imaging can rapidly determine the distribution of the constituents of a solid dosage form and elucidate the arrangement of excipients versus active ingredient across a tablet. “Simple spectroscopy can only provide single-point measurements at different wavelengths and generate an average measure,” says Dr. Neil Lewis of Spectral Dimensions. “On the other hand chemical imaging can capture full images at many different wavelengths, or at a series of selected wavelengths. This can support quickly and easily identifying subtle differences in the blend characteristics that may have a major impact on the final product performance.” The key hardware is both a high performance near infrared camera and a liquid crystal tunable filter which acts as a wavelength discriminator. These two components together support capture of images that present the distribution of multiple chemical components in a sample. Spectral Dimensions ISys, its software for the analysis of chemical imaging data, can then analyze the collected images as hyperspectral data, and create both visualizations and quantitative analysis. During production, blend image data may be acquired for regulatory or archival purposes but the goal here is real-time monitoring and control. “What you really want are numbers that tell you whether to stop or continue blending,” Lewis observes. . This quick, one-time registration gives you access to members-only site benefits. Link to this article from your web site or blog Copyright © 2004 — 2009 Pharma Manufacturing.