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Advances in pH Measurement in High-Temperature Biotech Processes

By CD Feng, Emerson Process Management, Rosemount Analytical Liquid pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. Yet pH measurement in various industrial processes still heavily relies upon century-old pH glass electrode technology, due to its reliable performance and robustness. However, with growing demand for increased accuracy of pH measurement and operational life of sensors, new technologies are emerging—especially regarding sensor durability in high-temperature steam-sterilization processes. This article presents recent research on the aging mechanism of the pH-sensing glass after hightemperature exposure by using the non-destructive complex impedance spectrum method. The aging behavior of new high-temperature glass formulations in steam-sterilizable sensors, as well as the
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pH Electrodes
pH electrodes are analytical sensors for measuring potential of hydrogen (pH), the negative logarithm of the hydrogen ion activity in solution.
pH Transmitters
pH transmitters provide electrical outputs that are proportional to potential of hydrogen (pH) inputs.
pH Instruments
pH instruments are used to measure or monitor potential of hydrogen (pH) in a solution.
Oxidation Reduction Potential (ORP) Electrodes
Oxygen reduction potential (ORP) electrodes are analytical sensors for measuring oxidation-reduction potential (ORP).
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By CD Feng, Emerson Process Management, Rosemount Analytical Liquid pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. Yet pH measurement...

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