(Gas Sensing)
From this Article:
It is essential to any cleaning validation program that analytical methods are selected appropriately for their intended use. Analytical methods should be able to adequately determine that a validated... (View Full Article)
(Lab Supplies)
From this Article:
Virtually every pharmaceutical or biopharma company we work with today is interested in minimizing the downtime associated with their validated equipment cleaning processes. They agree that this... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
The use of total organic carbon (TOC) in cleaning validation has become a widespread best practice throughout the pharmaceutical industry as an analytical method designed to verify the performance of... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
The first instrument requirement for the total organic carbon test detailed by the Japanese Pharmacopeia (JP) in the General Tests section <2.59> specifies that the instrument be capable of measuring... (View Full Article)
(Environmental Sensors)
From this Article:
A company's inability to detect and quickly react to organic breakthrough in steam condensate water can result in a significant productivity loss.... (View Full Article)
(Environmental Sensors)
From this Article:
A company's inability to recognize real-time organic loading changes in their wastewater treatment plant could result in excessive charges from the local water utility.... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
Traditional cleaning validation and verification approaches tend to focus on complex limits equations, inefficient recovery studies, costly product-specific method development, "pass/fail"... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
Since purchasing the instruments, STS has successfully validated the Sievers InnovOx TOC Analyzers to the requirements of the Environment Agency's MCerts scheme for waste water analysis and the... (View Full Article)
(Environmental Sensors)
From this Article:
The US Environmental Protection Agency (EPA) amended the Safe Drinking Water Act (SDWA) in 1996 to balance the risks presented by microbial pathogens and by-products from the disinfectant used to... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
In 2011, almost three times as many US FDA warning letters and FDA Form 483s were issued to pharmaceutical and biopharmaceutical manufacturers compared to 2010. The companies receiving these citations... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
Using a process capability approach based on historical or current total organic carbon (TOC) data for swab and rinse samples can demonstrate whether the cleaning process and the limits used for this... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
On April 1, 2012, the United States Pharmacopeia (USP) published the removal of the legacy Oxidizable Substance Test for the water monographs, Sterile Water for Injection (WFI), Sterile Purified Water... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
In December 2009, the US FDA conducted a 12- day inspection of a US pharmaceutical company. Subsequently, the FDA issued a Form 483 and listed their observations made during the facility inspection In... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
OCWD prides itself in not only using a cutting edge treatment system, but also utilizing analytical equipment to ensure the water being reintroduced into the ground is the highest quality. Monitoring... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
The goal of any cleaning validation program is to reduce the opportunity for product contamination or compound carryover that may be present on the production equipment. The validation of this type of... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
As many municipalities strive to balance regulations set forth in the USEPA's Safe Drinking Water Act, they are growing more concerned about how to reduce spending in their plant treatment processes.... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
A leading pharmaceutical manufacturer with high production demands faced cleaning validation challenges. This company's mature, validated production facility was expanding the amount of products they... (View Full Article)
(Environmental Sensors)
From this Article:
The Global Petroleum Research Institute (GPRI) at Texas A&M University-College Station regularly conducts laboratory research studies on various oil and gas produced wastewaters with varying sample... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
The Sievers* 900 and 5310 C Series TOC Analyzers incorporate a number of new features and options designed toimprove the accuracy and linearity of the TOC measurements. Three new calibration options... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
The food and beverage industry uses extraordinarily large amounts of water within their manufacturing processes. Water can be used as an ingredient, a cleaning solvent, and as a utility, such as for... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
Interest in Total Organic Carbon (TOC) analysis as a non-specific method for cleaning validation has grown considerably during the past decades because specific analytical testing, like High... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
Corrosion in boiler systems can quickly result in tube failure and plant shutdown. A properly-operating deaerator and an appropriate chemical program will greatly extend boiler life by addressing... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
In 1996, the Oxidizable Substances Test was replaced with Total Organic Carbon (TOC) testing for purified water and water for injection. The rationale behind this change was that the century-old... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
The monitoring, control, and optimization of organics in these applications are generally done using the Total Organic Carbon (TOC) method. The challenge then becomes finding a robust TOC analyzer... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
TOC, an operator tool, spans a wide variety of applications, and is widely thought of as a tool to help a utility comply with DBP regulations, but it also assists with cost savings from optimizing a... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
Biochemical Oxygen Demand (BOD) and Chemical Oxygen Demand (COD) are traditional parameters analyzed in the laboratory to determine organic matter in water and wastewater. Wastewater facility... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
TOC Correlation Data... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
The United States Food and Drug Administration (FDA) and its international equivalents, have stipulated longstanding regulations designed to serve the public with respect to controlling the strength,... (View Full Article)
(Gas Sensing)
From this Article:
Numerous studies have been conducted to compare the performance of various TOC methodologies on a wide range of raw source water and finished drinking water samples. The methodologies studied are... (View Full Article)
(Gas Sensing)
From this Article:
The use of total organic carbon (TOC) measurements has become a widespread best practice throughout the pharmaceutical, semiconductor, municipal water treatment, and wastewater industries. Many... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
Pharmaceutical drug manufacturers looking for gains in quality and efficiency have led to a growing interest in using Sievers* Total Organic Carbon (TOC) Analyzers for cleaning validation. Most... (View Full Article)
(Environmental Sensors)
From this Article:
Industrial wastewater is a result of manufacturing, agricultural, environmental, and research activities. Managing the treatment and discharge of industrial effluents is a critical process that... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
During the flooding, the Cobb County - Marietta Water Authority realized the importance of knowing more than just the turbidity levels in their source water. By identifying TOC values, the plant was... (View Full Article)
(Environmental and Water Quality Instruments)
From this Article:
Implementing or driving a cleaning validation project can be a "roller coaster" of emotions and challenges. Here's an annotated graph of what it's like to drive a cleaning validation project when... (View Full Article)