Also to be introduced this year, Paradis notes, are production-scale (up to 200-mm-diameter) supercritical fluid chromatography (SFC) systems. Pall is also seeing customers expand applications of its Mustang membrane chromatography line. "Manufacturers are starting to use membrane adsorbers not only for polishing downstream, but also further upstream in the capture steps," Jones says. Membrane adsorbers are being used to protect high-value chromatography media by removing increasing amounts of endotoxins, viral contaminants, and chromosomal DNA debris that may result from the higher protein titers being seen upstream. (Goettingen, Germany) continues to be at the forefront of membrane chromatography with its Sartobind line. The company has increased the loading capacity of Sartobind Q for MAb polishing 10.9 kg MAb per liter sorbent, says Jeff Mora, product manager for membrane chromatography. This allows just one to two liters of Sartobind to clear contaminants and viruses from a 15,000-liter MAb production run. A 1- or 2-liter membrane is approximately 200 times smaller than a column for the same unit operation, and the membrane can process five to 10 times faster, Mora says. The smaller sorbent volume means 95% less buffer consumption, and thus cost savings. As with other disposables, Sartobind SingleSep Q capsules are disposable and carry no cleaning validation or initial hardware costs, says Mora. (Kyoto, Japan) HPLC production-scale chromatography products in the U.S. last year. Custom production systems include pumping skids, sample loading devices, detection, fraction collection and software, says Seika president Ernest Sobkow. It also has dynamic axial compression systems (column and options) from (Kyoto, Japan) in diameters ranging from 5 to 60 cm and lengths of 70 and 100 cm. On the biochromatography side, Seika is positioning three different flow rate ranges for isocratic and gradient skids. The systems may be sold with production-scale glass columns from TechniKrom has shifted
Products & Services
Chromatography membranes are designed for separation tasks in laboratory and industrial applications. They are built-in membrane systems such as plate and frame, spiral-wound module, hollow fibre module, and tube-in-shell module.
Membrane bioreactor systems combine ultra-filtration technology with biological treatment for municipal, commercial and industrial wastewater treatment and water reuse applications.
Gas chromatography detectors (GC detectors) identify solutes as they exit the chromatographic column. A chromatogram is generated plotting the signal versus time.
A Watersurplus pilot plant is a small chemical processing system designed to generate information about the operation of the system to be used in engineering and designing a larger facility.
Topics of Interest
While truly groundbreaking innovations in chromatography equipment happen every blue moon, there have been noteworthy gradual improvements in the areas of chromatography media, column packing and...
Filters, membranes, and bioseparation equipment and supplies Filters used by IVD manufacturers encompass both simple materials (e.g., cellulose paper for liquid absorption or clarification) and...
This quick, one-time registration gives you access to members-only site benefits. For manufacturing therapeutic proteins, chromatography is nothing less than the Holy Grail of...
In plasma manufacturing, Martin says, charge-depth and viral filtration can be used to remove prions, as can membrane chromatography. However, viral filtration can only remove prions that have...
This quick, one-time registration gives you access to members-only site benefits. Dedicated viral clearance filtration is usually deployed as far downstream as possible due to the membranes...