More Than a Reagent Dispenser

While traditional handheld pipettes or larger automated liquid dispensers greatly deteriorate in accuracy and precision below 2 µL volumes, the Mantis automated liquid dispenser excels at low-volume dispensing in a wide variety of scientific workflows.

The system is an easy and affordable solution to quickly increase the reproducibility and quality of your research as well as the throughput and efficiency of your laboratory. The diaphragm-based chip design is liquid class compatible, easily dispensing aqueous and organic solutions. Additionally, the Mantis will dispense in any SBS template from 6 to 1536 well plates and can be easily programmed to dispense to custom designs as needed.

Mantis®

Precise Liquid Dispenser

A compact, programmable dispenser built for workflows where every nanoliter counts from master mix preparation to sensitive cell and bead dispensing.

Benefits

High Precision and Reproducibility: Dispense volumes as low as 100 nL with exceptional consistency (CV < 2%), enabled by the new High-Fidelity Chips that ensure even tighter control over dispense accuracy and precision

Efficient: Miniaturize reactions, scale up throughput, save on reagents, and remove pipette tip cost, saving time and resources across the board

Tackle High-Viscosity and Diverse Reagents: The continuous flow chips enable accurate dispensing of thick fluids like 70% glycerol, DMSO, beads, and mastermix—ensuring broad reagent compatibility for various workflows

Reliability and Traceability with Every Dispense: The Mantis ensures reliable dispensing with droplet verification, real-time LED status, automated breach detection, and RFID tracking for accurate, traceable results and enhanced uptime across your workflows

Fast, Error-Free Setup with CSV Templates: Seamlessly import CSV templates for quick and error-free experiment setup, streamlining workflows and reagent normalization

Fast Labware Setup with Intuitive Control: Define labware in seconds with the Interactive Labware Teaching module, and enjoy a streamlined setup process through an intuitive user interface

Compatible with a Broader Range of Plates: The Adaptable Plate Clamp is gentle enough to accommodate even thin-bottomed plates

Biosafety Cabinet Compatible: With its compact dimensions (350 mm x 232 mm x 212 mm), the Mantis can be used in various biosafety cabinets to accommodate workflows that require this level of safety

Automation Friendly: Integrate effortlessly with external systems, fostering connectivity and data synchronization

Seamless Operation in Regulatory Environments: The system features optional 21 CFR Part 11 Capable Software

Small Footprint: All these new features are packed within the same small footprint

Broad Range of Applications

• Assay Development and Design of Experiment (DoE)
• Next Generation Sequencing (NGS) - Library Preparation
• Polymerase Chain-reaction (PCR) Workflows Real-time and Digital
• Enzyme-Linked Immunosorbent Assays (ELISA)
• Cell Culture and Bead-Based Assays
• Scaling Up Organoid Cultures
• 3D Cell Culture

Enjoy Peace of Mind that Your Dispenses were Precise and Accurate

Optimize your workflow and ensure reliable results with the new Quality Control (QC) Droplet Detection Station. The QC station uses LEDs and optical sensors to confirm proper chip function by detecting the presence of dispensed drops. This technology allows the Mantis to automatically verify if drops are dispensed at the beginning and end of each run, providing both further confidence in dispense quality and traceability. This feature also eliminates the need for manual priming, saving you time and minimizing the risk of errors. With the QC station, you can have complete confidence that your Mantis chips are functioning properly throughout the dispensing process, delivering trustworthy results.

arge Capacity Chip Changer (LC3) Upgrade

The LC3 enhances the Mantis system by allowing storage for up to 24 chips with a single LC3, or up to 48 chips when using a dual LC3 configuration. This upgrade is fully integrated into the Mantis software, enabling seamless operation. It also incorporates RFID technology to automatically identify all chips stored on the LC3. The LC3 is available as an option with new Mantis instruments or can be added as an upgrade to existing units.

Enhance Laboratory Efficiency

Efficient research means that reagent dead volumes, tip consumption, and reaction volumes are minimized.  

The Mantis liquid dispenser dispenses volumes from 100 nL to 100s of mL allowing researchers to commonly run 2-5 µL reaction volumes in genomics and screening workflows.

To minimize dead volume, reagents plug directly into the microfluidic chip. Dead volumes are further reduced to just 6 μL by using pipette tips as reagent reservoirs, making the Mantis ideal for dispensing even the most precious reagents.

Normalize Your Assay Plate, Quickly and Easily

Streamline your assay plate preparation with precision and speed. The Mantis liquid dispenser simplifies normalization by combining intelligent software with our high-performance chip technology:

• The Mantis software automatically calculates the normalization values for you
• The Continuous Flow (CF) chip bulk dispenses at >600 µL/sec, quickly normalizing each sample tube, well, and plate
• Dispense high viscous solvents such as 100% glycerol using High Viscosity CF chip

Dispense Beads and Cells with Ease

Magnetic beads are an efficient means for extracting and purifying nucleic acids. Conventional pipetting may result in the non-uniform dispensing of mag beads, leading to a lack of reproducibility. The ability of the Mantis to precisely dispense high viscosity liquids allows uniform dosing of beads reducing operating costs and plastic waste.

Cells can be extremely sensitive, requiring additional care during handling, making the scalability of assays very challenging. The dispensing action of the Mantis liquid dispenser is gentle enough to dispense even the most delicate cells, such as primary neurons, while maintaining cell viability.

Use of Microfluidic Technology in Mantis

At the core of our dispensers is patented microdiaphragm pump that meters and dispenses discrete volumes of liquid. This valve cluster can fill and dispense as fast as 10 times per second (exact speed depends on specific product). This proven technology is both incredibly precise and viscosity independent.

Automated Dispensing, Now for Harsh Chemicals

The Mantis XL Chip is our largest-volume diaphragm chip, enabling accurate 50 µL dispensing in a single actuation. Designed with a perfluoroelastomer (PFE) diaphragm and fluorinated ethylene propylene (FEP) body, it delivers exceptional chemical compatibility for aggressive solvents and corrosive reagents. With CV < 2%, dead volume as low as 70 µL, and no calibration required, the XL PFE Chip brings new levels of robustness, scalability, and precision to demanding chemistry workflows.