Novel Compounds From Natural Products In The New Millennium: Potential and Challenges

Chapter 4: Bioinformatics Species Diversity Databases: Tools for Facilitating Natural Product Research

Sudershan Kumar and Vidhi Gupta
National Botanical Research Institute, Rana Pratap Marg, P.B. NO. 436 Lucknow-226 001 (UP) India

INTRODUCTION

Molecular Bioinformatics has acquired great importance due to its recent application in vast amount of data generated in the Human Genome sequence projects. The nature and priorities of bioinformatics research and applications are changing in several ways, viz. comparative genomics, functional genomics, proteomics and structural genomics.

Bioinformatics tools can be used to obtain sequences of genes or proteins of interest, either from material obtained, labeled, prepared and examined in electric fields by individual researchers/groups or from repositories of sequences from previously investigated material. The collecting, organizing and indexing of sequence information into a database, a challenging task in itself, provides the scientist with a wealth of information, albeit of limited use. The power of a database comes not from the collection of information, but in its analysis. A sequence of DNA does not necessarily constitute a gene. It may constitute only a fragment of a gene or alternatively, it may contain several genes. PCAPSS (Protein Classification through the Assessment of Predicted Secondary Structure), BLAST Filter, SeqCheck and SeqMake are a few notable tools of Molecular Bioinformatics.

About 6 billion people on this planet consume 40% of the planet s annual biological productivity. By the middle of 2020 25, about two thirds of living organisms will face the danger of extinction. In this era of maximum destruction, it has become a global priority to organize information by using modern bioinformatics tools, while at...

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