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  • A Spectroscopy Guide for PAT
    , crushability, surface area, porosity, morphology and particle size distribution of excipients and APIs. Standard physical testing, while accurate, is slow and labor-intensive. Means are needed to make rapid, multivariate measurements on solid materials. This suggests spectroscopy. This article
  • A Spectroscopy Guide for PAT
    , crushability, surface area, porosity, morphology and particle size distribution of excipients and APIs. Standard physical testing, while accurate, is slow and labor-intensive. Means are needed to make rapid, multivariate measurements on solid materials. This suggests spectroscopy. This article will
  • Using NIR Spectroscopy for Raw Materials Characterization
    raw material that was greatly increasing in quantity was Metformine Hydrochloride. At a standard weight of 25 kg per container, this raw material was originally analyzed using IR spectroscopy. This method proved no longer viable when the number of containers of Metformine Hydrochloride began
  • A Spectroscopy Guide for PAT
    are commercially available and are in use in process and off-campus activities. One limitation of this technique is the difficulty in absolute quantification. Since the intensity of the incident radiation determines the Raman spectrum and there is no "blank " or zero absorption, the standard I/Io
  • USP's Gary Ritchie with an Update on PAT Standards Development
    At IFPAC, Emil Ciurczak interviewed Gary Ritchie, Scientific Fellow for Process Analytical Technologies (PAT) at USP, for a review of PAT standards development within USP, with a special focus on 1119, the general chapter for NIR spectroscopy. The interview transcript follows. To hear the audio
  • Drying Requires Functional Model
    At Interphex 2008 in Philadelphia, David Radspinner, chairman of the ASTM E-5503 subcommittee on general pharmaceutical standards and marketing manager with Thermo Fisher Scientific, shared his views on Process Analytical Technologies (PAT) and Quality by Design (QbD). In order for the industry
  • Ultrasonics Beats Optical Methods for Measuring Some Critical Attributes
    and mechanical attributes of pharmaceutical ingredients that are critical to product quality are not easily achievable with standard spectroscopy
  • Leaning on NIR in Pisa
    products, and the company has laboratories dealing with QC (chemical and microbiological), pharmaceutical develop-ment (analytical development, QC of medicinal products and formulation) and research. Prior to adopting NIR spectroscopy for raw material analysis, Abiogen used individual methods for each raw

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