Overview

Many of the methods described in this book could not be applied routinely without the aid of some convenient piece of statistical software. Fortunately, many excellent statistical packages are now widely available, although our intention in this appendix is not to attempt either a comprehensive review or critique. Instead, we shall give details of packages that we feel are most suitable for specific applications and analyses. Links to web pages for a wide variety of statistical software can be found at:

http://www.stata.com/support/links/stat_software.htm1

1 SOFTWARE FOR SAMPLE SIZE DETERMINATION

nQuery Advisor Version 2.0: A package for choosing an appropriate sample size for many types of design and analysis including two-sample and paired t-tests, analysis of variance, crossover designs, nonparametric tests, survival analysis and regression. Very simple to use and well described is the user manual written by Janet D. Elashoff.

Available from:

• Statistical Solutions Ltd. 8 South Bank, Crosse's Green, Cork, Ireland: Tel +353 21 319629, Fax +353 21 319630:

  http://www.statsol.ie:

• In the USA, Boston, MA, USA 1-800-262-1171:

  http://www.statsolusa.com: http://www.infostatsolusa.com

MS-DOS 3.1 or higher, Microsoft Windows 3.1, Windows 95 or Windows NT is required.

A large number of other software packages for estimating sample size when designing studies can be found on:

http://www.interchg.ubc.ca/cacb/power

2 SOFTWARE FOR MULTIPLE IMPUTATION OF MISSING VALUES

Software is available from Statistical Solutions (address above) and from:

http://www.stat.psu.edu/?jls/misoftwa.html

3 SOFTWARE FOR INTERIM ANALYSIS

• EaSt, Version 2: Cytel Software Corporation, 675 Massachusetts Ave., Cambridge, MA 98195, USA.

• PEST3, Planning and Evaluation of Sequential Trials:...