Fundamental Toxicology

F-O

fecundity
  1. Ability to produce offspring frequently and in large numbers.

  2. In demography, the physiological ability to reproduce.

feromone

See pheromone.

fertility
Ability to conceive and to produce offspring: for litter-bearing species the number of offspring per litter is used as a measure of fertility.
Note

Reduced fertility is sometimes referred to as subfertility.

fetotoxicity
Toxicity to
fetus (often incorrectly foetus)
Young mammal within the uterus of the mother from the visible completion of characteristic organogenesis until birth.
Note

In humans, this period is usually defined as from the third month after fertilisation until birth (prior to this, the young mammal is referred to as an embryo).

fibrosis
Abnormal formation of fibrous tissue.
first-order process
  1. Chemical reaction where the rate is directly proportional to the concentration of reactant.

  2. Any process changing at a constant fractional rate.

first-pass effect
Biotransformation and, in some cases, elimination of a substance in the liver after absorption from the intestine and before it reaches the systemic circulation.
first-pass metabolism

See also first-pass effect.

fixed-dose procedure
Acute toxicity test in which a substance is tested initially at a small number (3 or 4) predefined doses to identify which produces evident toxicity without lethality: the test may be repeated at one or more higher or lower defined discriminating doses to satisfy the criteria.
fluorosis
Adverse effects of fluoride, as in dental or skeletal fluorosis.
foci (singular focus)
Small groups of cells distinguishable, in appearance or histochemically, from the...

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