Fundamental Toxicology

Appendix C: Abbreviations and Acronyms Used in Toxicology

ADI

Acceptable daily intake

AF

Assessment factor

ALARA(P)

As low as reasonably achievable (practicable) In UK, regulations relating to worker exposure In USA, goal of risk management (NRC regulations)

AUC

Area under the concentration-time curve

AUMC

Area under the moment curve

BCF

Bioconcentration factor

BEI

Biological exposure indices (ACGIH)

BEM

Biological effect monitoring

BOD

Biochemical oxygen demand

b.w.

Body weight

CMR

Carcinogenic, mutagenic and reproductive (toxicant)

CoMFA

Comparative molecular field analysis

CV

Ceiling value

Cyt

Cytochrome

DNA

Deoxyribonucleic acid

DNEL

Derived no-effect level

EC

Enzyme classification or effective concentration

EC n

Median effective concentration to n% of a population

EDI

Estimated daily intake

ED n

Median effective dose to n% of a population

EEC

Estimated exposure concentration

EED

Estimated exposure dose

EEL

Environmental exposure level

EMDI

Estimated maximum daily intake

EQS

Environmental quality standard

GLP

Good laboratory practice

HSG

Health and safety guide (IPCS)

HQ

Hazard quotient

IC

Inhibitory concentration

i.c.

Intracutaneous

i.d.

Intradermal

i.m.

Intramuscular

inhl

By inhalation

i.p.

Intraperitoneal

I-TEF

International toxicity equivalency factor

i.v.

Intravenous

K M

Michaelis constant

K oc

Organic carbon partition coefficient

K OW

Octanol water partition coefficient

LADD

Lifetime average daily dose

LC n

Median concentration lethal to n% of a test population

LC 50

See LC n

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