Hazardous Chemicals Handbook, Second Edition

Risk Assessment of Carcinogens

Arguably, risk assessment from exposure to carcinogens merits special consideration because of the low levels of exposure capable of producing an adverse response in certain individuals coupled with the often long time-lag (latency period) between exposure and onset of disease.

There are several formal lists of carcinogens. Thus, in the UK under the Control of Substances Hazardous to Health Regulations 1999 (see later) carcinogens are defined as:

  • Any substance or preparation which if classified in accordance with the classification provided for by regulation 5 of the Chemicals (Hazard Information and Packaging for Supply) Regulations 1994 ('CHIPS') as amended would be in the category of danger, carcinogenic (category 1) or carcinogenic (category 2).

  • Substances listed in Table 5.15.

Table 5.15: Substances and processes to which the definition of 'carcinogen' relates

Aflatoxins

Arsenic

Auramine manufacture

Calcining, sintering or smelting of nickel copper matte or acid leaching or electrorefining of roasted matte

Coal soots, coal tar, pitch and coal tar fumes

Hardwood dusts

Isopropyl alcohol manufacture (strong acid process)

Leather dust in boot and shoe manufacture, arising during preparation and finishing

Magenta manufacture

Mustard gas ( ?, ? -dichlorodiethyl sulphide)

Rubber manufacturing and processing giving rise to rubber process dust and rubber fume

Used engine oils

Substances or preparations requiring to be labelled with the risk phrase 'R45' (may cause cancer) or 'R49' (may cause cancer by inhalation) under 'CHIPS' are listed in Table 5.16 after the 5th edition of the Approved Supply List (Information approved for the...

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