Plasma Source Mass Spectrometry: Applications and Emerging Technologies

Section 1: Bio-Analytical Applications

CHAPTER LIST

Chapter 1: Simultaneous Quantitation of Specific Proteins Using Immunoassay ICP-MS
Chapter 2: New Challenges for ICP-MS Instrumentation and Data Acquisition. Solving Problems of Real Life Biology
Chapter 3: Some Applications of ICP-MS in the Pharmaceutical Industry
Chapter 4: Quantitation of Phosphorus in Biologically Active Materials By ICP-MS Detection of P and S with Chemical Resolution
Chapter 5: Application of Sector-field ICP-MS and ICP-MS with Collision Cell for Determination of Phosphorus and Iron in Proteins
Chapter 6: Combination of ICP-MS and Ion Exchange Chromatography Permits Analyses of Specific Cisplatin Dna Modifications Formed in Cancer Cells
Chapter 7: Conventional and Chromatographic ICPMS Analysis of Cisplatin and Carboplatin in Plasma and Plasma Ultrafiltrate
Chapter 8:Determination, by ICP-MS, of Background and BBR 3464 Induced Levels of Platinum Bound to DNA Isolated from Blood Cells: A Comparison of the Sensitivity of the Perkin Elmer Sciex Elan 6000 and the Thermofinnigan Neptune Instruments

Zo A. Quinn, Vladimir I. Baranov and Scott D. Tanner

MDS SCIEX, 71 Four Valley Drive, Concord, Ontario, Canada L4K 4V8

1 INTRODUCTION

ICP-MS has been used for many biological applications in the past, including: the quantitation of toxic elements in blood and other body fluids; studying the transport and destiny of metals in vivo; monitoring the absorption and metabolism of both nutrient metals and metallo-drugs; characterizing metallo-proteins and metal homologues of amino acids and stable isotope tracing (uptake, metabolism, diagnostics). Typically in all these methods, the bio-molecules analyzed with the ICP-MS are already associated with a metal component. However...

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