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  • Prions Come Under Closer Scrutiny
    In plasma manufacturing, Martin says, charge-depth and viral filtration can be used to remove prions, as can membrane chromatography. However, viral filtration can only remove prions that have aggregated. Ion-exchange column chromatography can be used to remove individual prions, but the columns
  • Bioseparations, the Evolution Continues
    Long the workhorse of bioseparation, chromatography also is getting its share of process improvements. Traditional gel media, for example, are notoriously difficult to scale up: as columns become taller, huge pressure drops cause gels to compress, changing the physics of media adsorption. "The only
  • Downstream Bioprocessing: More is More
    , not virus removal. Validating virus retention and/or elution through columns adds an unnecessary step to the viral clearance exercise. Chemical inactivation works well enough, especially when combined with orthogonal methods, but removing the spent chemical treatment adds a processing step. Sartorius

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