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  • Proper Calibration Techniques (.pdf)
    ) of the reference electrode, by comparing these values to those of known buffer solutions. The EXA Instruments utilize preprogrammed buffer tables in the Auto Cal function. These pre-programmed values are based on pure N.I.S.T. buffers, which correspond to 6.86 pH, 4.01 pH and 9.18 pH at 25° C.
  • Medical Device Link . Microspheres, part 2:
    ), buffer pH should be at, or slightly more basic than, IgG's isoelectric point (that is, pH 8), where the protein is in its most relaxed, compact form ( ). Gibbs and colleagues (Costar Corp., Kennebunkport, ME) say, "Binding is favored when pH is close, but not equal to, the pI [isoelectric point
  • Guided Wave Radar at Genentech: A Novel Technique for Non-invasive Volume Measurement in Disposable Bioprocess Bags
    By Bryan Bean, Tim Matthews, Neria Daniel, Steve Ward, Brad Wolk, Genentech, Inc. Disposable bioprocess bags are increasingly being used in biopharmaceutical operations for buffer storage, buffer and media prep, bioreactors, product pooling and storage of bulk drug substance. Disposables offer
  • Medical Device Link . Stability issues for protein-based in vitro diagnostic products
    to the shelf life of dried components. Liquid stabilization is affected by a larger number of variables. Temperature, microbial contamination, and pH level or buffer can all affect stability. Additionally, this article will discuss why performance problems should not be automatically attributed
  • Chromatography Roundup
    While truly groundbreaking innovations in chromatography equipment happen every blue moon, there have been noteworthy gradual improvements in the areas of chromatography media, column packing and on-line buffer blending, say Howard Levine (president) and Tom Ransohoff (consultant) of BioProcess

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