IC Mask Design: Essential Layout Techniques

"Ok," Bill thinks to himself. "Let's write these points down before I forget them."
Current can be as high as 5 milliamps.
Cross-quad the input pair.
Need extra well and substrate ties.
Rotate 90 to improve current flow.
Q:
If you were Bill, where would you start?
Answers
Q:
You could start with any of these four issues. There is no right or wrong order to doing layout work.
"Ok, let's look at each of these issues one at a time," Bill thinks. "Cross-quading would mess up the diagram the most, and rotating 90 is a big issue, too.
"Well, the first item I want to tackle, maybe, are the little things. Just get them out of the way. Knock them off quickly.
"On the other hand, by the time I handle the large items, they could rearrange my whole floorplan. The layout might be totally different in the end, so all that work on the little things could be wasted.
"Well, on the other hand, I could just throw my substrate contacts down at the bottom and get it over with. I was taught to place them early to guarantee room for them.
"On the other hand, there might not be room at the bottom after I make the big changes."
Bill feels he has run out of hands, detects his gut feeling, and quickly knows his decision. "That's it. What I really want to do is start with the big stuff.